Micky van de Ven Brace Ends Everton's Unbeaten Streak at Brand New Home Ground
The Dutch defender became the first backline player to score two goals in a English top-flight game for Spurs since Jan Vertonghen in March 2013.
At a glance
Micky Van de Ven nods home twice in opening period
The home side's Jake O'Brien has equalizer ruled after VAR review
Senegalese midfielder nets third in 89th minute
The defeat is Everton's first at Hill Dickinson Stadium
The Tottenham defender scored on two occasions as Spurs prolonged their unbeaten run on the road in the Premier League and handed the Toffees their first defeat at their new home.
The Toffees were unbeaten in their last five matches at their new ground at the dockside location, having left Goodison Park behind after 133 years at the end of the previous campaign.
But Spurs captain the Dutchman pounced twice from set-pieces in the first half to put their impressive record at jeopardy, and they were unable to turn it around before Pape Matar Sarr - assisted by ex-Everton forward Richarlison - headed home a final goal to seal the victory.
The Everton defender thought he had equalized the scores five minutes after the defender's opener, directing a bullet header past Guglielmo Vicario from an Everton corner.
Beto, in the meantime, failed to convert a number of opportunities, while Vicario made a series of excellent saves to ensure Tottenham went five matches on the road unbeaten in the Premier League.
But the video assistant referee intervened, instructing Craig Pawson to review the goal on the pitchside monitor and the referee decided that Jack Grealish and Iliman Ndiaye were in an illegal position and had interfered with the Spurs keeper.
This victory moves the manager's team into third place in the division, a handful of points off local foes and leaders the Gunners.
The Merseyside club remain 14th and sit half a dozen points ahead of the drop zone.
Spurs breakdown: Van de Ven fulfils duties at each end of pitch
Following a drab midweek performance in the European competition against the French side, where they managed a only attempts on target, the manager opted for Randal Kolo Muani in attack instead of former Toffees player the Brazilian.
The summer signing was unable to make much of an impact before being replaced for the substitute after an hour on the pitch, but it emerged he wasn't needed in the end.
Defender Van de Ven transformed into an offensive threat to be feared.
Spurs' first goal came from a well-worked corner routine, with the midfielder heading the ball back across the face of goal for an free Van de Ven to score.
And the captain - filling in as skipper in the Argentine's unavailability - notched his next goal in added time as he outjumped the England keeper to nod in.
The Dutchman was just as impressive in defensive duties, partnering well with his defensive colleague as the pair handled superbly with the numerous deliveries sent their way by Everton.
Everton analysis: Toffees missing striker's instinct
The club's new home had been a happy hunting ground, but it seems the novelty may have faded somewhat and fans flocked to the gates after the midfielder's third for Tottenham.
The end in the team's unbeaten home run won't be a massive worry for the manager, but their attacking woes are.
The forward and the other striker - the Toffees' two recognised centre-forwards - had netted just one league goal combined before Sunday's outing.
And they were unable to contribute to that poor record on a damp and dreary night on in Liverpool.
The striker's form was summed up when he opted to bicycle-kick a golden opportunity from close range, even with having room and opportunity to reposition for a simpler shot that would have tested the keeper.
The substitute, as well, was unable to influence the game after coming on for the starter in the 65th minute.
It was not for a lack of opportunity. Most of Everton's attacks came through the winger and Ndiaye, who relentlessly whipped threatening balls into the Spurs box.
Upcoming fixtures for these two sides?
Everton: The team head to the Stadium of Light in the Premier League on Monday, 3 November at 20:00 GMT.
Tottenham: The London club travel to St James' Park on Wednesday, 29 October for their next round League Cup match against the Magpies.